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LSD d-lysergic acid diethylamide is one of the most potent mood- and perception-altering hallucinogenic drugs. It is a clear or white, odorless, water-soluble material synthesized from lysergic acid, a compound derived from a rye fungus. The most common form, however, is LSD-soaked paper punched into small individual squares. Psilocybin 4-phosphoryloxy-N,N-dimethyltryptamine is extracted from certain types of mushrooms found in tropical and subtropical regions of South America, Mexico, and the United States.
In the past, psilocybin was ingested during religious ceremonies by indigenous cultures from Mexico and Central America. Psilocybin can either be dried or fresh and eaten raw, mixed with food, or brewed into a tea, and produces similar effects to LSD. Peyote Mescaline is a small, spineless cactus with mescaline as its main ingredient. It has been used by natives in northern Mexico and the southwestern United States as a part of religious ceremonies. Because the extract is so bitter, some users prepare a tea by boiling the plant for several hours.
Mescaline can also be produced through chemical synthesis.
Synthetic DMT usually takes the form of a white crystalline powder and is typically vaporized or smoked in a pipe. Ayahuasca is a hallucinogenic brew made from one of several Amazonian plants containing DMT the primary psychoactive ingredient along with a vine containing a natural alkaloid that prevents the normal breakdown of DMT in the digestive tract.
Ayahuasca tea has traditionally been used for healing and religious purposes in indigenous South American cultures, mainly in the Amazon region. PCP Phencyclidine was originally developed in the s as a general anesthetic for surgery. While it can be found in a variety of forms, including tablets or capsules, it is usually sold as a liquid or powder.
PCP can be snorted, smoked, injected, or swallowed. It is sometimes smoked after being sprinkled on marijuana, tobacco, or parsley.
Ketamine is a dissociative currently used as an anesthetic for humans as well as animals. Much of the ketamine sold on the street has been diverted from veterinary offices. Although it is manufactured as an injectable liquid, ketamine is generally evaporated to form a powder that is snorted or compressed into pills for illicit use. Because ketamine is odorless and tasteless and has amnesia-inducing properties, it is sometimes added to drinks to facilitate sexual assault. DXM Dextromethorphan is a cough suppressant and expectorant ingredient in some over-the-counter OTC cold and cough medications that are often abused by adolescents and young adults.
Salvia divinorum is a psychoactive plant common to southern Mexico and Central and South America. Salvia is typically ingested by chewing fresh leaves or by drinking their extracted juices. The dried leaves of salvia can also be smoked or vaporized and inhaled. National Institutes of Health.
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Therapeutic Use of LSD in Psychiatry: A Systematic Review of Randomized-Controlled Clinical Trials