Nitrous oxide and the brain

Added: Krieg Celaya - Date: 01.05.2022 00:50 - Views: 21950 - Clicks: 4497

Study record managers: refer to the Data Element Definitions if submitting registration or information. Seed-to-whole brain functional connectivity Fisher's r-transformed z will be measured from the left anterior insula, ly shown to be involved in pain and sensory processing.

Paired t-test were conducted on subject specific beta maps to identify changes in connectivity associated with nitrous oxide in SPM The z-score descriptors represent the Fishers-r-to-z transformed. Here the z-score is a transformation of the Pearson's r correlation coefficient of the BOLD timeseries between two brain regions.

Higher z-scores are associated with higher correlations in timeseries and correspond with higher functional connectivity between two brain regions. Functional Connectivity Associated With Tonic Stimulus [ Time Frame: Baseline to 50 minutes ] Functional connectivity measures will be assessed at rest baseline and during a tonic cuff stimulus 6-minutes. Spectral Power of Sub-anesthetic Dose of Nitrous Oxide [ Time Frame: Baseline to 50 minutes ] Brain imaging data will be obtained from functional magnetic resonance imaging fMRI data recorded simultaneously with electroencephalogram EEG data at baseline and under a sub-anesthetic dose of nitrous oxide.

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Spectral data during the baseline and sub-anesthetic dose of nitrous to observe changes in spectral power. Talk with your doctor and family members or friends about deciding to a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or information.

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Search for terms x. Save this study. Warning You have reached the maximum of saved studies Network-Level Effects of Nitrous Oxide in the Human Brain The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. First Posted : July 9, Last Update Posted : July 9, Study Description. The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain.

Nitrous oxide is commonly used in anesthesiology but there is limited knowledge on how this drug affects functional networks in the brain. Detailed Description:. The objective of this study is to identify the network transformations that for the analgesic effects of nitrous oxide.

Our hypothesis is that analgesic doses of nitrous oxide increase network efficiency and disrupt normal pain processingOur approach is to administer subanesthetic nitrous oxide during the acquisition of fMRI functional magnetic resonance imaging and EEG electroencephalogram.

FDA Resources. Arms and Interventions. Outcome Measures. Primary Outcome Measures : Functional Connectivity During Nitrous Oxide [ Time Frame: Baseline to 50 minutes ] Functional connectivity measures will be assessed at rest baseline and during sub anesthetic dose nitrous oxide nitrous oxide.

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Functional connectivity measures will be assessed at rest baseline and during a tonic cuff stimulus 6-minutes. Brain imaging data will be obtained from functional magnetic resonance imaging fMRI data recorded simultaneously with electroencephalogram EEG data at baseline and under a sub-anesthetic dose of nitrous oxide. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.

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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Drug: Nitrous Oxide Gas for Inhalation. Phase 4. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Actual Study Start Date :. Actual Primary Completion Date :. Actual Study Completion Date :.

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February 15, Key Record Dates.

Nitrous oxide and the brain

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Nitrous Oxide (Laughing Gas)